Scientific articles & patents

Please find below selected patents and scientific articles on the antibody microarray platform or its application in biomedical studies for a protein profiling published in peer-reviewed journals. The articles were either published by our customers or by the founders and employees of Sciomics.

Selected scientific articles by our customers and partner

2022

• Abdulkhalikova D, Sustarsic A, Vrtačnik Bokal E, Jancar N, Jensterle M and Burnik Papler T. 2022
  The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity.
  Front Endocrinol. 13:888460. doi:10.3389/fendo.2022.888460.
• Franz S, Ertel A, Engel KM, Simon JC, Saalbach A. 2022
  Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing.
  Theranostics. 12(4):1659-1682. doi:10.7150/thno.67174. 
• Grötsch B., Schachtschabel E., Tripal P., Schmid B., Smith A., Schett G.A. and Bozec A. 2022
  Inflammatory activation of FcgR and IFNgR pathways co-influence the differentiation and activity of osteoclasts.
  Front. Immunol. 13:958974. doi:10.3389/fimmu.2022.958974
• Labes R, Brinkmann L, Kulow VA, Roegner K, Mathia S, Balcerek B, Persson PB, Rosenberger C and Fähling M. 2022
  Daprodustat prevents cyclosporine-A mediated anemia and peritubular capillary loss.
  Kidney Int. S0085-2538(22)00375-1. doi:10.1016/j.kint.2022.04.025. 
• Marino, D., Pizzi, M., Kotova, I., Schmidt, R., Schröder, C., Guzzardo, V., Talli, I., Peroni, E., Finotto, S., Scapinello, G., Dei Tos, A.P., Piazza, F., Trentin, L., Zagonel, V. and Piovan, E., 2022.
  High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients.
  Cancers 14. https://doi.org/10.3390/cancers14020338
• Pušić M, Klančič T, Knific T, Vogler A, Schmidt R, Schröder C and Lanišnik Rižner T. 2022.
  Antibody Arrays Identified Cycle-Dependent Plasma Biomarker Candidates of Peritoneal Endometriosis.
  J Pers Med. 12(6):852. doi: 10.3390/jpm12060852.
• Watson, C.N., Begum, G., Ashman, E., Thorn, D., Yakoub, K.M., Hariri, M.A., Nehme, A., Mondello, S., Kobeissy, F., Belli, A. and Di Pietro, V., 2022.
  Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients.
  Cells 11, 163. https://doi.org/10.3390/cells11010163

2021

• Awwad, M.H.S., Mahmoud, A., Bruns, H., Echchannaoui, H., Kriegsmann, K., Lutz, R., Raab, M.S., Bertsch, U., Munder, M., Jauch, A., Weisel, K., Maier, B., Weinhold, N., Salwender, H.J., Eckstein, V., Hänel, M., Fenk, R., Dürig, J., Brors, B., Benner, A., Müller-Tidow, C., Goldschmidt, H., Hundemer, M., 2021.
  Selective elimination of immunosuppressive T cells in patients with multiple myeloma.
  Leukemia 35, 2602–2615. https://doi.org/10.1038/s41375-021-01172-x

• Fomitcheva-Khartchenko, A., Rapsomaniki, M.A., Sobottka, B., Schraml, P., Kaigala, G.V., 2021. 
  Spatial protein heterogeneity analysis in frozen tissues to evaluate tumor heterogeneity.
  PLOS ONE 16, e0259332. https://doi.org/10.1371/journal.pone.0259332

• Janša, V., Klančič, T., Pušić, M., Klein, M., Vrtačnik Bokal, E., Ban Frangež, H., Rižner, T.L., 2021.
  Proteomic analysis of peritoneal fluid identified COMP and TGFBI as new candidate biomarkers for endometriosis.
  Sci Rep 11, 20870. https://doi.org/10.1038/s41598-021-00299-2
• Jarazo, J., Barmpa, K., Modamio, J., Saraiva, C., Sabaté‐Soler, S., Rosety, I., Griesbeck, A., Skwirblies, F., Zaffaroni, G., Smits, L.M., Su, J., Arias‐Fuenzalida, J., Walter, J., Gomez‐Giro, G., Monzel, A.S., Qing, X., Vitali, A., Cruciani, G., Boussaad, I., Brunelli, F., Jäger, C., Rakovic, A., Li, W., Yuan, L., Berger, E., Arena, G., Bolognin, S., Schmidt, R., Schröder, C., Antony, P.M.A., Klein, C., Krüger, R., Seibler, P., Schwamborn, J.C., 2021.
  Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐CyclodextrinTreatment.
  Mov Disord mds.28810. https://doi.org/10.1002/mds.28810
• Kowtharapu, B.S., Damaraju, J., Singh, N.K., Ziebart, J., Bader, R., Koczan, D., Stachs, O., 2021.
  Analysis of the Differential Gene and Protein Expression Profiles of Corneal Epithelial Cells Stimulated with Alternating Current Electric Fields.
  Genes 12, 299. https://doi.org/10.3390/genes12020299
• Lange, C., Weber, A.M., Schmidt, R., Schroeder, C., Strowitzki, T., Germeyer, A., 2021.
  Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line.
  PLOS ONE 16, e0248103. https://doi.org/10.1371/journal.pone.0248103

2020

• Boberg, E., Kadri, N., Winterling, J., Davies, L.C., Björklund, A., Msghina, M., Iacobaeus, E., Le Blanc, K., 2020.
  Mental fatigue after allogeneic hematopoietic stem cell transplantation is associated with cognitive dysfunction, but not central nervous system inflammation.
  Haematologica 105, e310–e314. https://doi.org/10.3324/haematol.2019.225326
• Fernando, R., Wardelmann, K., Deubel, S., Kehm, R., Jung, T., Mariotti, M., Vasilaki, A., Gladyshev, V.N., Kleinridders, A., Grune, T., Castro, J.P., 2020.
  Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration.
  Redox Biology 32, 101507. https://doi.org/10.1016/j.redox.2020.101507
• Fiorentino, F.P., Marchesi, I., Schröder, C., Schmidt, R., Yokota, J., Bagella, L., 2020.
  BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells.
  Int J Mol Sci 21. https://doi.org/10.3390/ijms21249595
• Yin, Y., Shelke, G.V., Lässer, C., Brismar, H., Lötvall, J., 2020.
  Extracellular vesicles from mast cells induce mesenchymal transition in airway epithelial cells.
  Respiratory Research 21, 101. https://doi.org/10.1186/s12931-020-01346-8

2019 and older

• Fultang, L., Gamble, L.D., Gneo, L., Berry, A.M., Egan, S.A., De Bie, F., Yogev, O., Eden, G.L., Booth, S., Brownhill, S., Vardon, A., McConville, C.M., Cheng, P.N., Norris, M.D., Etchevers, H.C., Murray, J., Ziegler, D.S., Chesler, L., Schmidt, R., Burchill, S.A., Haber, M., De Santo, C., Mussai, F., 2019.
  Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma.
  Cancer Res 79, 611–624. https://doi.org/10.1158/0008-5472.CAN-18-2139
• Reichman, H., Itan, M., Rozenberg, P., Yarmolovski, T., Brazowski, E., Varol, C., Gluck, N., Shapira, S., Arber, N., Qimron, U., Karo-Atar, D., Lee, J.J., Munitz, A., 2019.
  Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer.
  Cancer Immunol Res 7, 388–400. https://doi.org/10.1158/2326-6066.CIR-18-0494
• Kowtharapu, B.S., Murín, R., Jünemann, A.G.M., Stachs, O., 2018.
  Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing.
  International Journal of Molecular Sciences 19, 464. https://doi.org/10.3390/ijms19020464
• Peiro, J.L., Oria, M., Aydin, E., Joshi, R., Cabanas, N., Schmidt, R., Schroeder, C., Marotta, M., Varisco, B.M., 2018.
  Proteomic profiling of tracheal fluid in an ovine model of congenital diaphragmatic hernia and fetal tracheal occlusion.
  Am J Physiol Lung Cell Mol Physiol 315, L1028–L1041. https://doi.org/10.1152/ajplung.00148.2018
• Thorenz, A., Derlin, K., Schröder, C., Dressler, L., Vijayan, V., Pradhan, P., Immenschuh, S., Jörns, A., Echtermeyer, F., Herzog, C., Chen, R., Rong, S., Bräsen, J.H., Kooten, C. van, Kirsch, T., Klemann, C., Meier, M., Klos, A., Haller, H., Hensen, B., Gueler, F., 2018.
  Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis.
  Kidney International 94, 741–755. https://doi.org/10.1016/j.kint.2018.04.005
• Hamidi, Z., Tejero, E., Schmidt, R., Tucker, R., Pedro, A., 2017.
  Identification of potential blood-derived extracellular vesicles biomarkers to diagnose and predict distant metastases in ER+ breast cancer patients.
  bioRxiv 202291. https://doi.org/10.1101/202291
• Sass, F.A., Schmidt‐Bleek, K., Ellinghaus, A., Filter, S., Rose, A., Preininger, B., Reinke, S., Geissler, S., Volk, H.-D., Duda, G.N., Dienelt, A., 2017.
  CD31+ Cells From Peripheral Blood Facilitate Bone Regeneration in Biologically Impaired Conditions Through Combined Effects on Immunomodulation and Angiogenesis.
  Journal of Bone and Mineral Research 32, 902–912. https://doi.org/10.1002/jbmr.3062
• Bakdash, G., Buschow, S.I., Gorris, M.A.J., Halilovic, A., Hato, S.V., Sköld, A.E., Schreibelt, G., Sittig, S.P., Torensma, R., Duiveman-de Boer, T., Schröder, C., Smits, E.L., Figdor, C.G., de Vries, I.J.M., 2016.
  Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines.
  Cancer Res 76, 4332–4346. https://doi.org/10.1158/0008-5472.CAN-15-1695

Selected scientific articles by our founders and employees

• Marino, D., Pizzi, M., Kotova, I., Schmidt, R., Schröder, C., Guzzardo, V., Talli, I., Peroni, E., Finotto, S., Scapinello, G., Dei Tos, A.P., Piazza, F., Trentin, L., Zagonel, V., Piovan, E., 2022.
  High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients.
  Cancers 14. https://doi.org/10.3390/cancers14020338
• Jarazo, J., Barmpa, K., Modamio, J., Saraiva, C., Sabaté‐Soler, S., Rosety, I., Griesbeck, A., Skwirblies, F., Zaffaroni, G., Smits, L.M., Su, J., Arias‐Fuenzalida, J., Walter, J., Gomez‐Giro, G., Monzel, A.S., Qing, X., Vitali, A., Cruciani, G., Boussaad, I., Brunelli, F., Jäger, C., Rakovic, A., Li, W., Yuan, L., Berger, E., Arena, G., Bolognin, S., Schmidt, R., Schröder, C., Antony, P.M.A., Klein, C., Krüger, R., Seibler, P., Schwamborn, J.C., 2022.
  Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐CyclodextrinTreatment.
  Mov Disord mds.28810. https://doi.org/10.1002/mds.28810
• Pušić M, Klančič T, Knific T, Vogler A, Schmidt R, Schröder C, Lanišnik Rižner T. 2022.
  Antibody Arrays Identified Cycle-Dependent Plasma Biomarker Candidates of Peritoneal Endometriosis.
  J Pers Med. 12(6):852. doi: 10.3390/jpm12060852.
• Janša, V., Klančič, T., Pušić, M., Klein, M., Vrtačnik Bokal, E., Ban Frangež, H., Rižner, T.L., 2021.
  Proteomic analysis of peritoneal fluid identified COMP and TGFBI as new candidate biomarkers for endometriosis.
  Sci Rep 11, 20870. https://doi.org/10.1038/s41598-021-00299-2
• Lange, C., Weber, A.M., Schmidt, R., Schroeder, C., Strowitzki, T., Germeyer, A., 2021.
  Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line.
  PLOS ONE 16, e0248103. https://doi.org/10.1371/journal.pone.0248103
• Fiorentino, F.P., Marchesi, I., Schröder, C., Schmidt, R., Yokota, J., Bagella, L., 2020.
  BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells.
  International Journal of Molecular Sciences 21, 9595. https://doi.org/10.3390/ijms21249595
• Fultang, L., Gamble, L.D., Gneo, L., Berry, A.M., Egan, S.A., Bie, F.D., Yogev, O., Eden, G.L., Booth, S., Brownhill, S., Vardon, A., McConville, C.M., Cheng, P.N., Norris, M.D., Etchevers, H.C., Murray, J., Ziegler, D.S., Chesler, L., Schmidt, R., Burchill, S.A., Haber, M., Santo, C.D., Mussai, F., 2019.
  Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma.
  Cancer Res 79, 611–624. https://doi.org/10.1158/0008-5472.CAN-18-2139
• Thorenz, A., Derlin, K., Schröder, C., Dressler, L., Vijayan, V., Pradhan, P., Immenschuh, S., Jörns, A., Echtermeyer, F., Herzog, C., Chen, R., Rong, S., Bräsen, J.H., Kooten, C. van, Kirsch, T., Klemann, C., Meier, M., Klos, A., Haller, H., Hensen, B., Gueler, F., 2018.
  Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis.
  Kidney International 94, 741–755. https://doi.org/10.1016/j.kint.2018.04.005
• Peiro, J.L., Oria, M., Aydin, E., Joshi, R., Cabanas, N., Schmidt, R., Schroeder, C., Marotta, M., Varisco, B.M., 2018.
  Proteomic profiling of tracheal fluid in an ovine model of congenital diaphragmatic hernia and fetal tracheal occlusion.
  American Journal of Physiology-Lung Cellular and Molecular Physiology 315, L1028–L1041. https://doi.org/10.1152/ajplung.00148.2018
• Bakdash, G., Buschow, S.I., Gorris, M.A.J., Halilovic, A., Hato, S.V., Sköld, A.E., Schreibelt, G., Sittig, S.P., Torensma, R., Boer, T.D., Schröder, C., Smits, E.L., Figdor, C.G., Vries, I.J.M. de, 2016.
  Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines.
  Cancer Res 76, 4332–4346. https://doi.org/10.1158/0008-5472.CAN-15-1695
• Kibat, J., Schirrmann, T., Knape, M.J., Helmsing, S., Meier, D., Hust, M., Schröder, C., Bertinetti, D., Winter, G., Pardes, K., Funk, M., Vala, A., Giese, N., Herberg, F.W., Dübel, S., Hoheisel, J.D., 2016.
  Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality.
  N Biotechnol 33, 574–581. https://doi.org/10.1016/j.nbt.2015.12.003
• Betzen, C., Alhamdani, M.S.S., Lueong, S., Schröder, C., Stang, A., Hoheisel, J.D., 2015.
  Clinical proteomics: Promises, challenges and limitations of affinity arrays.
  PROTEOMICS – Clinical Applications 9, 342–347. https://doi.org/10.1002/prca.201400156
• Nijaguna, M.B., Schröder, C., Patil, V., Shwetha, S.D., Hegde, A.S., Chandramouli, B.A., Arivazhagan, A., Santosh, V., Hoheisel, J.D., Somasundaram, K., 2015.
  Definition of a serum marker panel for glioblastoma discrimination and identification of Interleukin 1β in the microglial secretome as a novel mediator of endothelial cell survival induced by C-reactive protein.
  Journal of Proteomics 128, 251–261. https://doi.org/10.1016/j.jprot.2015.07.026
• Srinivasan, H., Allory, Y., Sill, M., Vordos, D., Alhamdani, M.S.S., Radvanyi, F., Hoheisel, J.D., Schröder, C., 2014.
  Prediction of recurrence of non muscle-invasive bladder cancer by means of a protein signature identified by antibody microarray analyses.
  PROTEOMICS 14, 1333–1342. https://doi.org/10.1002/pmic.201300320
• Hoheisel, J.D., Alhamdani, M.S.S., Schröder, C., 2013.
  Affinity-based microarrays for proteomic analysis of cancer tissues.
  PROTEOMICS – Clinical Applications 7, 8–15. https://doi.org/10.1002/prca.201200114
• Schröder, C., Srinivasan, H., Sill, M., Linseisen, J., Fellenberg, K., Becker, N., Nieters, A., Hoheisel, J.D., 2013.
  Plasma protein analysis of patients with different B-cell lymphomas using high-content antibody microarrays.
  PROTEOMICS – Clinical Applications 7, 802–812. https://doi.org/10.1002/prca.201300048
• Alhamdani, M.S.S., Youns, M., Buchholz, M., Gress, T.M., Beckers, M.-C., Maréchal, D., Bauer, A., Schröder, C., Hoheisel, J.D., 2012.
  Immunoassay-based proteome profiling of 24 pancreatic cancer cell lines.
  Journal of Proteomics, 3747–3759. https://doi.org/10.1016/j.jprot.2012.04.042
• Alhamdani, M.S.S., Schröder, C., Hoheisel, J.D., 2010.
  Analysis conditions for proteomic profiling of mammalian tissue and cell extracts with antibody microarrays.
  PROTEOMICS 10, 3203–3207. https://doi.org/10.1002/pmic.201000170
• Alhamdani, M.S.S., Schröder, C., Werner, J., Giese, N., Bauer, A., Hoheisel, J.D., 2010.
  Single-Step Procedure for the Isolation of Proteins at Near-Native Conditions from Mammalian Tissue for Proteomic Analysis on Antibody Microarrays.
  J. Proteome Res. 9, 963–971. https://doi.org/10.1021/pr900844q
• Schröder, C., Jacob, A., Tonack, S., Radon, T.P., Sill, M., Zucknick, M., Rüffer, S., Costello, E., Neoptolemos, J.P., Crnogorac-Jurcevic, T., Bauer, A., Fellenberg, K., Hoheisel, J.D., 2010.
  Dual-color Proteomic Profiling of Complex Samples with a Microarray of 810 Cancer-related Antibodies.
  Molecular & Cellular Proteomics 9, 1271–1280. https://doi.org/10.1074/mcp.M900419-MCP200
• Sill, M., Schröder, C., Hoheisel, J.D., Benner, A., Zucknick, M., 2010.
  Assessment and optimisation of normalisation methods for dual-colour antibody microarrays.
  BMC Bioinformatics 11, 556. https://doi.org/10.1186/1471-2105-11-556
• Kusnezow, W., Banzon, V., Schröder, C., Schaal, R., Hoheisel, J.D., Rüffer, S., Luft, P., Duschl, A., Syagailo, Y.V., 2007.
  Antibody microarray-based profiling of complex specimens: systematic evaluation of labeling strategies.
  PROTEOMICS 7, 1786–1799. https://doi.org/10.1002/pmic.200600762

Selected patents with contribution of our platform

• WO2021175863A1: Method for diagnosis and/or prognosis of liver disease progression and risk of hepatocellular carcinoma and discovery of therapeutic compounds and targets to treat liver disease and cancer
• WO2021162554A1: Means and methods for determining mesenchymal stromal cell properties.
• US20210137912A1: s)-2-(1-(5-(cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acid for use in medicine
• EP2536844B1, US9551035B2: Means and methods for diagnosing pancreatic cancer
• EP2718720B1, US9678075B2: Prediction of recurrence for bladder cancer by a protein signature in tissue samples