Please find below selected patents and scientific articles on the antibody microarray platform or its application in biomedical studies for a protein profiling published in peer-reviewed journals. The articles were either published by our customers or by the founders and employees of Sciomics.
Selected scientific articles by our customers and partner
2023
- Fiedler MK, Drechsel J, Schmidt R, Luppa PB, Bach NC, Sieber SA. (2023)
Rapid Diagnostic Platform for Personalized Vitamin B6 Detection in Erythrocytes via PLP Cofactor Mimics.
ACS Chem Biol. Jul 5. doi: 10.1021/acschembio.3c00279. Epub ahead of print. - Galadima, M.; Kotova, I.; Schmidt, R.; Pastor, J.; Schröder, C.; Rodríguez-Gil, J.E.; del Alamo, M.M.R. (2023)
Canine Mammary Neoplasia Induces Variations in the Peripheral Blood Levels of CD20, CD45RA, and CD99.
Int. J. Mol. Sci., 24, 9222. https://doi.org/10.3390/ijms24119222 - Tintelnot, J., Xu, Y., Lesker, T. R., Schönlein, M., Konczalla, L., Giannou, A. D., Pelczar, P., Kylies, D., Puelles, V. G., Bielecka, A. A., Peschka, M., Cortesi, F., Riecken, K., Jung, M., Amend, L., Bröring, T. S., Trajkovic-Arsic, M., Siveke, J. T., Renné, T., Zhang, D., … Gagliani, N. (2023).
Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer.
Nature, 615(7950), 168–174. https://doi.org/10.1038/s41586-023-05728-y - Wiedmann, L., De Angelis Rigotti, F., Vaquero-Siguero, N., Donato, E., Espinet, E., Moll, I., Alsina-Sanchis, E., Bohnenberger, H., Fernandez-Florido, E., Mülfarth, R., Vacca, M., Gerwing, J., Conradi, L. C., Ströbel, P., Trumpp, A., Mogler, C., Fischer, A., & Rodriguez-Vita, J. (2023).
HAPLN1 potentiates peritoneal metastasis in pancreatic cancer.
Nature communications, 14(1), 2353. https://doi.org/10.1038/s41467-023-38064-w
2022
- Abdulkhalikova D, Sustarsic A, Vrtačnik Bokal E, Jancar N, Jensterle M and Burnik Papler T. 2022
The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity.
Front Endocrinol. 13:888460. doi:10.3389/fendo.2022.888460. - Franz S, Ertel A, Engel KM, Simon JC, Saalbach A. 2022
Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing.
Theranostics. 12(4):1659-1682. doi:10.7150/thno.67174. - Grötsch B., Schachtschabel E., Tripal P., Schmid B., Smith A., Schett G.A. and Bozec A. 2022
Inflammatory activation of FcgR and IFNgR pathways co-influence the differentiation and activity of osteoclasts.
Front. Immunol. 13:958974. doi:10.3389/fimmu.2022.958974 - Labes R, Brinkmann L, Kulow VA, Roegner K, Mathia S, Balcerek B, Persson PB, Rosenberger C and Fähling M. 2022
Daprodustat prevents cyclosporine-A mediated anemia and peritubular capillary loss.
Kidney Int. S0085-2538(22)00375-1. doi:10.1016/j.kint.2022.04.025. - Marino, D., Pizzi, M., Kotova, I., Schmidt, R., Schröder, C., Guzzardo, V., Talli, I., Peroni, E., Finotto, S., Scapinello, G., Dei Tos, A.P., Piazza, F., Trentin, L., Zagonel, V. and Piovan, E., 2022.
High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients.
Cancers 14. https://doi.org/10.3390/cancers14020338 - Pušić M, Klančič T, Knific T, Vogler A, Schmidt R, Schröder C and Lanišnik Rižner T. 2022.
Antibody Arrays Identified Cycle-Dependent Plasma Biomarker Candidates of Peritoneal Endometriosis.
J Pers Med. 12(6):852. doi: 10.3390/jpm12060852. -
Watson, C.N., Begum, G., Ashman, E., Thorn, D., Yakoub, K.M., Hariri, M.A., Nehme, A., Mondello, S., Kobeissy, F., Belli, A. and Di Pietro, V., 2022.Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients.Cells 11, 163. https://doi.org/10.3390/cells11010163
2021
- Awwad, M.H.S., Mahmoud, A., Bruns, H., Echchannaoui, H., Kriegsmann, K., Lutz, R., Raab, M.S., Bertsch, U., Munder, M., Jauch, A., Weisel, K., Maier, B., Weinhold, N., Salwender, H.J., Eckstein, V., Hänel, M., Fenk, R., Dürig, J., Brors, B., Benner, A., Müller-Tidow, C., Goldschmidt, H., Hundemer, M., 2021.
Selective elimination of immunosuppressive T cells in patients with multiple myeloma.
Leukemia 35, 2602–2615. https://doi.org/10.1038/s41375-021-01172-x -
Fomitcheva-Khartchenko, A., Rapsomaniki, M.A., Sobottka, B., Schraml, P., Kaigala, G.V., 2021.
Spatial protein heterogeneity analysis in frozen tissues to evaluate tumor heterogeneity.
PLOS ONE 16, e0259332. https://doi.org/10.1371/journal.pone.0259332 - Janša, V., Klančič, T., Pušić, M., Klein, M., Vrtačnik Bokal, E., Ban Frangež, H., Rižner, T.L., 2021.
Proteomic analysis of peritoneal fluid identified COMP and TGFBI as new candidate biomarkers for endometriosis.
Sci Rep 11, 20870. https://doi.org/10.1038/s41598-021-00299-2 -
Jarazo, J., Barmpa, K., Modamio, J., Saraiva, C., Sabaté‐Soler, S., Rosety, I., Griesbeck, A., Skwirblies, F., Zaffaroni, G., Smits, L.M., Su, J., Arias‐Fuenzalida, J., Walter, J., Gomez‐Giro, G., Monzel, A.S., Qing, X., Vitali, A., Cruciani, G., Boussaad, I., Brunelli, F., Jäger, C., Rakovic, A., Li, W., Yuan, L., Berger, E., Arena, G., Bolognin, S., Schmidt, R., Schröder, C., Antony, P.M.A., Klein, C., Krüger, R., Seibler, P., Schwamborn, J.C., 2021.
Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐CyclodextrinTreatment.
Mov Disord mds.28810. https://doi.org/10.1002/mds.28810 - Kowtharapu, B.S., Damaraju, J., Singh, N.K., Ziebart, J., Bader, R., Koczan, D., Stachs, O., 2021.
Analysis of the Differential Gene and Protein Expression Profiles of Corneal Epithelial Cells Stimulated with Alternating Current Electric Fields.
Genes 12, 299. https://doi.org/10.3390/genes12020299 -
Lange, C., Weber, A.M., Schmidt, R., Schroeder, C., Strowitzki, T., Germeyer, A., 2021.
Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line.
PLOS ONE 16, e0248103. https://doi.org/10.1371/journal.pone.0248103
2020
- Boberg, E., Kadri, N., Winterling, J., Davies, L.C., Björklund, A., Msghina, M., Iacobaeus, E., Le Blanc, K., 2020.
Mental fatigue after allogeneic hematopoietic stem cell transplantation is associated with cognitive dysfunction, but not central nervous system inflammation.
Haematologica 105, e310–e314. https://doi.org/10.3324/haematol.2019.225326 - Fernando, R., Wardelmann, K., Deubel, S., Kehm, R., Jung, T., Mariotti, M., Vasilaki, A., Gladyshev, V.N., Kleinridders, A., Grune, T., Castro, J.P., 2020.
Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration.
Redox Biology 32, 101507. https://doi.org/10.1016/j.redox.2020.101507 - Fiorentino, F.P., Marchesi, I., Schröder, C., Schmidt, R., Yokota, J., Bagella, L., 2020.
BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells.
Int J Mol Sci 21. https://doi.org/10.3390/ijms21249595 - Yin, Y., Shelke, G.V., Lässer, C., Brismar, H., Lötvall, J., 2020.
Extracellular vesicles from mast cells induce mesenchymal transition in airway epithelial cells.
Respiratory Research 21, 101. https://doi.org/10.1186/s12931-020-01346-8
2019 and older
- Fultang, L., Gamble, L.D., Gneo, L., Berry, A.M., Egan, S.A., De Bie, F., Yogev, O., Eden, G.L., Booth, S., Brownhill, S., Vardon, A., McConville, C.M., Cheng, P.N., Norris, M.D., Etchevers, H.C., Murray, J., Ziegler, D.S., Chesler, L., Schmidt, R., Burchill, S.A., Haber, M., De Santo, C., Mussai, F., 2019.
Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma.
Cancer Res 79, 611–624. https://doi.org/10.1158/0008-5472.CAN-18-2139 - Reichman, H., Itan, M., Rozenberg, P., Yarmolovski, T., Brazowski, E., Varol, C., Gluck, N., Shapira, S., Arber, N., Qimron, U., Karo-Atar, D., Lee, J.J., Munitz, A., 2019.
Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer.
Cancer Immunol Res 7, 388–400. https://doi.org/10.1158/2326-6066.CIR-18-0494 - Kowtharapu, B.S., Murín, R., Jünemann, A.G.M., Stachs, O., 2018.
Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing.
International Journal of Molecular Sciences 19, 464. https://doi.org/10.3390/ijms19020464 - Peiro, J.L., Oria, M., Aydin, E., Joshi, R., Cabanas, N., Schmidt, R., Schroeder, C., Marotta, M., Varisco, B.M., 2018.
Proteomic profiling of tracheal fluid in an ovine model of congenital diaphragmatic hernia and fetal tracheal occlusion.
Am J Physiol Lung Cell Mol Physiol 315, L1028–L1041. https://doi.org/10.1152/ajplung.00148.2018 - Thorenz, A., Derlin, K., Schröder, C., Dressler, L., Vijayan, V., Pradhan, P., Immenschuh, S., Jörns, A., Echtermeyer, F., Herzog, C., Chen, R., Rong, S., Bräsen, J.H., Kooten, C. van, Kirsch, T., Klemann, C., Meier, M., Klos, A., Haller, H., Hensen, B., Gueler, F., 2018.
Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis.
Kidney International 94, 741–755. https://doi.org/10.1016/j.kint.2018.04.005 - Hamidi, Z., Tejero, E., Schmidt, R., Tucker, R., Pedro, A., 2017.
Identification of potential blood-derived extracellular vesicles biomarkers to diagnose and predict distant metastases in ER+ breast cancer patients.
bioRxiv 202291. https://doi.org/10.1101/202291 - Sass, F.A., Schmidt‐Bleek, K., Ellinghaus, A., Filter, S., Rose, A., Preininger, B., Reinke, S., Geissler, S., Volk, H.-D., Duda, G.N., Dienelt, A., 2017.
CD31+ Cells From Peripheral Blood Facilitate Bone Regeneration in Biologically Impaired Conditions Through Combined Effects on Immunomodulation and Angiogenesis.
Journal of Bone and Mineral Research 32, 902–912. https://doi.org/10.1002/jbmr.3062 - Bakdash, G., Buschow, S.I., Gorris, M.A.J., Halilovic, A., Hato, S.V., Sköld, A.E., Schreibelt, G., Sittig, S.P., Torensma, R., Duiveman-de Boer, T., Schröder, C., Smits, E.L., Figdor, C.G., de Vries, I.J.M., 2016.
Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines.
Cancer Res 76, 4332–4346. https://doi.org/10.1158/0008-5472.CAN-15-1695
Selected scientific articles by our founders and employees
- Fiedler MK, Drechsel J, Schmidt R, Luppa PB, Bach NC, Sieber SA. (2023)
Rapid Diagnostic Platform for Personalized Vitamin B6 Detection in Erythrocytes via PLP Cofactor Mimics.
ACS Chem Biol. Jul 5. doi: 10.1021/acschembio.3c00279. Epub ahead of print. - Galadima, M.; Kotova, I.; Schmidt, R.; Pastor, J.; Schröder, C.; Rodríguez-Gil, J.E.; del Alamo, M.M.R. (2023)
Canine Mammary Neoplasia Induces Variations in the Peripheral Blood Levels of CD20, CD45RA, and CD99.
Int. J. Mol. Sci., 24, 9222. https://doi.org/10.3390/ijms24119222 - Hufnagel, K., Fathi, A., Stroh, N., Klein, M., Skwirblies, F., Girgis, R., Dahlke, C., Hoheisel, J. D., Lowy, C., Schmidt, R., Griesbeck, A., Merle, U., Addo, M. M., & Schröder, C. 2023.
Discovery and systematic assessment of early biomarkers that predict progression to severe COVID-19 disease.
Communications medicine, 3(1), 51. https://doi.org/10.1038/s43856-023-00283-z - Marino, D., Pizzi, M., Kotova, I., Schmidt, R., Schröder, C., Guzzardo, V., Talli, I., Peroni, E., Finotto, S., Scapinello, G., Dei Tos, A.P., Piazza, F., Trentin, L., Zagonel, V., Piovan, E., 2022.
High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients.
Cancers 14. https://doi.org/10.3390/cancers14020338 - Jarazo, J., Barmpa, K., Modamio, J., Saraiva, C., Sabaté‐Soler, S., Rosety, I., Griesbeck, A., Skwirblies, F., Zaffaroni, G., Smits, L.M., Su, J., Arias‐Fuenzalida, J., Walter, J., Gomez‐Giro, G., Monzel, A.S., Qing, X., Vitali, A., Cruciani, G., Boussaad, I., Brunelli, F., Jäger, C., Rakovic, A., Li, W., Yuan, L., Berger, E., Arena, G., Bolognin, S., Schmidt, R., Schröder, C., Antony, P.M.A., Klein, C., Krüger, R., Seibler, P., Schwamborn, J.C., 2022.
Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐CyclodextrinTreatment.
Mov Disord mds.28810. https://doi.org/10.1002/mds.28810 - Pušić M, Klančič T, Knific T, Vogler A, Schmidt R, Schröder C, Lanišnik Rižner T. 2022.
Antibody Arrays Identified Cycle-Dependent Plasma Biomarker Candidates of Peritoneal Endometriosis.
J Pers Med. 12(6):852. doi: 10.3390/jpm12060852. - Janša, V., Klančič, T., Pušić, M., Klein, M., Vrtačnik Bokal, E., Ban Frangež, H., Rižner, T.L., 2021.
Proteomic analysis of peritoneal fluid identified COMP and TGFBI as new candidate biomarkers for endometriosis.
Sci Rep 11, 20870. https://doi.org/10.1038/s41598-021-00299-2 -
Lange, C., Weber, A.M., Schmidt, R., Schroeder, C., Strowitzki, T., Germeyer, A., 2021.Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line.PLOS ONE 16, e0248103. https://doi.org/10.1371/journal.pone.0248103
- Fiorentino, F.P., Marchesi, I., Schröder, C., Schmidt, R., Yokota, J., Bagella, L., 2020.
BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells.
International Journal of Molecular Sciences 21, 9595. https://doi.org/10.3390/ijms21249595 - Fultang, L., Gamble, L.D., Gneo, L., Berry, A.M., Egan, S.A., Bie, F.D., Yogev, O., Eden, G.L., Booth, S., Brownhill, S., Vardon, A., McConville, C.M., Cheng, P.N., Norris, M.D., Etchevers, H.C., Murray, J., Ziegler, D.S., Chesler, L., Schmidt, R., Burchill, S.A., Haber, M., Santo, C.D., Mussai, F., 2019.
Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma.
Cancer Res 79, 611–624. https://doi.org/10.1158/0008-5472.CAN-18-2139 - Thorenz, A., Derlin, K., Schröder, C., Dressler, L., Vijayan, V., Pradhan, P., Immenschuh, S., Jörns, A., Echtermeyer, F., Herzog, C., Chen, R., Rong, S., Bräsen, J.H., Kooten, C. van, Kirsch, T., Klemann, C., Meier, M., Klos, A., Haller, H., Hensen, B., Gueler, F., 2018.
Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis.
Kidney International 94, 741–755. https://doi.org/10.1016/j.kint.2018.04.005 - Peiro, J.L., Oria, M., Aydin, E., Joshi, R., Cabanas, N., Schmidt, R., Schroeder, C., Marotta, M., Varisco, B.M., 2018.
Proteomic profiling of tracheal fluid in an ovine model of congenital diaphragmatic hernia and fetal tracheal occlusion.
American Journal of Physiology-Lung Cellular and Molecular Physiology 315, L1028–L1041. https://doi.org/10.1152/ajplung.00148.2018 - Bakdash, G., Buschow, S.I., Gorris, M.A.J., Halilovic, A., Hato, S.V., Sköld, A.E., Schreibelt, G., Sittig, S.P., Torensma, R., Boer, T.D., Schröder, C., Smits, E.L., Figdor, C.G., Vries, I.J.M. de, 2016.
Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines.
Cancer Res 76, 4332–4346. https://doi.org/10.1158/0008-5472.CAN-15-1695 - Kibat, J., Schirrmann, T., Knape, M.J., Helmsing, S., Meier, D., Hust, M., Schröder, C., Bertinetti, D., Winter, G., Pardes, K., Funk, M., Vala, A., Giese, N., Herberg, F.W., Dübel, S., Hoheisel, J.D., 2016.
Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality.
N Biotechnol 33, 574–581. https://doi.org/10.1016/j.nbt.2015.12.003 - Betzen, C., Alhamdani, M.S.S., Lueong, S., Schröder, C., Stang, A., Hoheisel, J.D., 2015.
Clinical proteomics: Promises, challenges and limitations of affinity arrays.
PROTEOMICS – Clinical Applications 9, 342–347. https://doi.org/10.1002/prca.201400156 - Nijaguna, M.B., Schröder, C., Patil, V., Shwetha, S.D., Hegde, A.S., Chandramouli, B.A., Arivazhagan, A., Santosh, V., Hoheisel, J.D., Somasundaram, K., 2015.
Definition of a serum marker panel for glioblastoma discrimination and identification of Interleukin 1β in the microglial secretome as a novel mediator of endothelial cell survival induced by C-reactive protein.
Journal of Proteomics 128, 251–261. https://doi.org/10.1016/j.jprot.2015.07.026 - Srinivasan, H., Allory, Y., Sill, M., Vordos, D., Alhamdani, M.S.S., Radvanyi, F., Hoheisel, J.D., Schröder, C., 2014.
Prediction of recurrence of non muscle-invasive bladder cancer by means of a protein signature identified by antibody microarray analyses.
PROTEOMICS 14, 1333–1342. https://doi.org/10.1002/pmic.201300320 - Hoheisel, J.D., Alhamdani, M.S.S., Schröder, C., 2013.
Affinity-based microarrays for proteomic analysis of cancer tissues.
PROTEOMICS – Clinical Applications 7, 8–15. https://doi.org/10.1002/prca.201200114 - Schröder, C., Srinivasan, H., Sill, M., Linseisen, J., Fellenberg, K., Becker, N., Nieters, A., Hoheisel, J.D., 2013.
Plasma protein analysis of patients with different B-cell lymphomas using high-content antibody microarrays.
PROTEOMICS – Clinical Applications 7, 802–812. https://doi.org/10.1002/prca.201300048 - Alhamdani, M.S.S., Youns, M., Buchholz, M., Gress, T.M., Beckers, M.-C., Maréchal, D., Bauer, A., Schröder, C., Hoheisel, J.D., 2012.
Immunoassay-based proteome profiling of 24 pancreatic cancer cell lines.
Journal of Proteomics, 3747–3759. https://doi.org/10.1016/j.jprot.2012.04.042 - Alhamdani, M.S.S., Schröder, C., Hoheisel, J.D., 2010.
Analysis conditions for proteomic profiling of mammalian tissue and cell extracts with antibody microarrays.
PROTEOMICS 10, 3203–3207. https://doi.org/10.1002/pmic.201000170 - Alhamdani, M.S.S., Schröder, C., Werner, J., Giese, N., Bauer, A., Hoheisel, J.D., 2010.
Single-Step Procedure for the Isolation of Proteins at Near-Native Conditions from Mammalian Tissue for Proteomic Analysis on Antibody Microarrays.
J. Proteome Res. 9, 963–971. https://doi.org/10.1021/pr900844q - Schröder, C., Jacob, A., Tonack, S., Radon, T.P., Sill, M., Zucknick, M., Rüffer, S., Costello, E., Neoptolemos, J.P., Crnogorac-Jurcevic, T., Bauer, A., Fellenberg, K., Hoheisel, J.D., 2010.
Dual-color Proteomic Profiling of Complex Samples with a Microarray of 810 Cancer-related Antibodies.
Molecular & Cellular Proteomics 9, 1271–1280. https://doi.org/10.1074/mcp.M900419-MCP200 - Sill, M., Schröder, C., Hoheisel, J.D., Benner, A., Zucknick, M., 2010.
Assessment and optimisation of normalisation methods for dual-colour antibody microarrays.
BMC Bioinformatics 11, 556. https://doi.org/10.1186/1471-2105-11-556 - Kusnezow, W., Banzon, V., Schröder, C., Schaal, R., Hoheisel, J.D., Rüffer, S., Luft, P., Duschl, A., Syagailo, Y.V., 2007.
Antibody microarray-based profiling of complex specimens: systematic evaluation of labeling strategies.
PROTEOMICS 7, 1786–1799. https://doi.org/10.1002/pmic.200600762
Selected patents with contribution of our platform
- WO2021175863A1: Method for diagnosis and/or prognosis of liver disease progression and risk of hepatocellular carcinoma and discovery of therapeutic compounds and targets to treat liver disease and cancer
- WO2021162554A1: Means and methods for determining mesenchymal stromal cell properties.
- US20210137912A1: s)-2-(1-(5-(cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acid for use in medicine
- EP2536844B1, US9551035B2: Means and methods for diagnosing pancreatic cancer
- EP2718720B1, US9678075B2: Prediction of recurrence for bladder cancer by a protein signature in tissue samples
